I originally played Fallout New Vegas on PS3, and because I enjoyed the first play through so much I decided to purchase the game again, this time on PC with all the DLC in one pack.
I'm only a couple of hours in so far and it certainly hasn't lost any of it's quality. In fact, it looks about a thousand times better on PC (no real surprise) and so a second play through with a different build, consciously making different decisions AND having the DLC to get through should be a great experience.
Also really enjoying Limbo and Braid at the moment - indietastic!