I've put about 40+ hours into this now and I have to say, I think it's simply superb.
When I first starting playing, I was enjoying it in a very similar way to my enjoyment of New Vegas. It ticked off many of the things I loved about that game and I would have been quite content for it to continue in a similar vein.
However, I have to say that as the hours have gone past i've noticed more and more detail of story, character and little touches throughout the world that really do put this head and shoulders above most games out there. It's an incredible experience, and worthy of everyones attention.