My last holiday in that abroadia was in Sicily (Pre-pandemic), we flew into Palermo Airport.
The only things I'd say about Palermo are that it is a bit of a hike from the Airport to the City (about an hour on the bus iirc) and that it was pretty much like a mid sized city on the Med, I wasn't there long enough to have an opinion as we caught a train from there along the North Coast to Cefalu, which I would recommend but not for a weekend as it's a lot of travel time to get there via bus and train.
Sicily in general is great though