Being from and currently living in New England which is a Blue stronghold with a cohesive identity separate from the rest of the country, I've often daydreamed about breaking off from the USA and forming our own republic.
But there are huge hurdles to clear to achieving that, and it would seem pretty unlikely. Despite our reputation for a better educated populace with better health, and better markers in general of a higher standard of living than most of the country, we also have entrenched MAGA gun nuts who would not want to be ruled over by "elitist liberals" in Boston and Cambridge.
If you have armed right wingers who don't recognize the authority of their new government, you've got a problem.
It might happen some day, but I won't be around to see it.