In the US, Ketamine therapy is becoming more accessible. There are clinics open in small town Maine now. I really hope this is a silver bullet for people who are at their wit's end. I don't have "major depression" and because of my less severe symptoms I might not qualify for this, but it looks very promising. Hopefully they lower the cost and/or it gets covered by insurance. And that anyone can access it, even people who only feel down during the winter months, which is probably most people.
https://www.nytimes.com/2021/05/30/opinion/ketamine-treatment-depression.html